Additional file 4.

Phylogenetic analysis of the CaMK group. Amino acid sequences of the catalytic domain of the CaMK proteins of S. mansoni (blue labels), C. elegans, D. melanogaster, S. cerevisiae, H. sapiens, and B. malayi were used to construct a distance-based phylogenetic tree using PHYLIP programs. Bootstrap values (1000 replicates) equal or higher than 80% are indicated (‚óŹ) as cutoff values to support the family/subfamily classification. Functional classification is indicated individually in the protein labels. Protein families are highlighted by the vertical bars and include: MAPKAPK (MAP Kinase Associated Protein Kinase), CAMK1 (CAMK family 1), PHK (Phosphorylase Kinase), Trio, DAPK (Death Associated Protein Kinase), MLCK (Myosin Light Chain Kinases), CASK, CAMK2 (CAMK family 2), DCAMKL (Doublecortin and CaMK-Like), PKD (Protein Kinase D), RAD53, Trbl, CAMKL (CAMKL-like).

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Andrade et al. BMC Genomics 2011 12:215   doi:10.1186/1471-2164-12-215