Additional file 2.

Phylogenetic analysis of the AGC group. Amino acid sequences of the catalytic domain of the AGC proteins of S. mansoni (blue labels), C. elegans, D. melanogaster, S. cerevisiae, H. sapiens, and B. malayi were used to construct a distance-based phylogenetic tree using PHYLIP programs. Bootstrap values (1000 replicates) equal or higher than 80% are indicated (‚óŹ) as cutoff values to support the family/subfamily classification. Functional classification is indicated individually in the protein labels. Protein families are highlighted by the vertical bars and include: RSK (Ribosomal S6 Kinase), PKA (Protein Kinase A), PKG (Protein Kinase G), PDK1(phosphoinositide-dependent protein kinase 1), NDR (nuclear Dbf2-related kinases), DMPK (Myotonic Dystrophy Protein Kinase), MAST (Microtubule Associated Serine/Threonine Kinase), RSKL (RSK-like); PKC (Protein Kinase C), PKN (Protein Kinase N), Akt (also known as PKB, Protein Kinase B), SGK (Serum and Glucocorticoid Resposive Kinase), GRK (G-protein coupled Receptor Kinase), YANK (Yet Another Novel Kinase).

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Andrade et al. BMC Genomics 2011 12:215   doi:10.1186/1471-2164-12-215