Distribution of ePKs groups in S. mansoni and model organisms. S. mansoni proteins were classified according to KinBase  by combining sequence searches (HMMs) and phylogenetic analysis. For comparison, occurrence of the ePKs in B. malayi, C. elegans, H. sapiens, D. melanogaster, S. cerevisiae, and is shown. The ePK groups include: PTK (Protein Tyrosine Kinase), AGC (cAMP-dependent protein kinase/protein kinase G/protein kinase C extended), CaMK (Calcium/Calmodulin regulated kinases), CMGC (Cyclin-dependent Kinases and other close relatives), CK1 (Cell Kinase I), STE (MAP Kinase cascade kinases), RGC (Receptor Guanylate Cyclases), TKL (Tyrosine Kinase Like), and Other.
Andrade et al. BMC Genomics 2011 12:215 doi:10.1186/1471-2164-12-215