Table 9

Top regulated adipocyte genes in epididymal adipocytes with age

Entrez Gene Name

14M

18M

P value (cell type*age)


UCP2

uncoupling protein 2

2.3

1.3

8.1E-061

LEPR

leptin receptor

1.3

-1.1

0.02

FGFR1

fibroblast growth factor receptor 1

1.3

-1.5

0.03

PLIN3

perilipin 3, TIP47

1.2

1.6

0.0007

PPARγ

peroxisome proliferator-activated receptor gamma

1.1

1.8

0.0003

PLIN2

Perilipin 2, adipophilin, ADFP

1

1.7

5.8E-05

ADIPOQ

Adiponectin

-1.2

1.2

0.01

FABP4

fatty acid binding protein 4, adipocyte

-1.2

-1.3

0.05

C/EBPα

CCAAT/enhancer binding protein, alpha

-1.3

1.1

0.01

PPARGC1α

peroxisome proliferator-activated receptor gamma, coactivator 1 alpha

-1.5

2

1.4E-05

ADIPOR2

adiponectin receptor 2

-1.6

-1.1

0.001

SOD2

superoxide dismutase 2, mitochondrial

-1.8

-1.1

0.0001

TNFα

TNFα

-2.3

-2.1

0.0001

C/EBPβ

CCAAT/enhancer binding protein, beta

-2.4

-1

1.4E-05

IRS2

insulin receptor substrate 2

-4.3

-2.8

1.2E-05

SERPINE1

plasminogen activator inhibitor type 1

-7.3

-4.3

0.0004

IL6

interleukin 6

-19.8

-4.8

8.3E-05


The list includes the adipocyte genes that change with age in epididymal adipocytes. The set of regulated genes was selected on the basis of their expression in adipose according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in epididymal adipocytes. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA.

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

Open Data