Table 6

Age-related fold changes in genes involved in lipolysis

Bone marrow

Epididymal

Symbol

Entrez Gene Name

14M

18M

14M

18M


ABHD5

αβ hydrolase domain containing 5

-1.12

-1.26

-1.97

1.04

ACACB

acetyl-CoA carboxylase beta

-1.40

-1.14

-2.22

-1.31

ADRB2

adrenergic, beta-2-, receptor, surface

1.22

1.49

-1.37

-2.04

C3

complement component 3

-1.07

-1.23

2.16

-1.11

EIF4EBP2

eukaryotic translation initiation factor 4E binding protein 2

-1.38

-1.53

-1.60

-1.15

FOXO1

forkhead box O1

1.99

1.17

-1.42

-1.44

GPR109A

G protein-coupled receptor 109A

-1.29

-3.99

-10.52

-2.20

NR4A1

nuclear receptor subfamily 4, group A, member 1

2.53

1.11

-4.03

-4.62

P2RY14

purinergic receptor P2Y, G-protein coupled, 14

1.07

1.05

1.54

-1.21

PDE3B

phosphodiesterase 3B, cGMP-inhibited

1.57

1.25

-1.99

-1.32

PLIN1

perilipin 1

-1.24

-1.21

-1.36

1.04

PNPLA2

patatin-like phospholipase domain containing 2

-1.03

-1.43

-1.39

-1.21

TNF

tumor necrosis factor

2.37

-1.38

-2.36

-2.12


The list includes age-related fold change in genes involved in lipolysis in bone marrow and epididymal adipocytes. The set of regulated genes was selected according to the IPA knowledge-base. The 14-month (14M) and 18-month-old (18M) were compared to 6-month-old. The significance of differences was measured by two-way ANOVA. The significance of differences was estimated by a Benjamini-Hochberg corrected p value (p < 0.01).

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

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