Table 4

Top regulated pathways in bone marrow and epididymal adipocytes with age

Genes

Genes assigned


Pathway

Cell type

Age (M)

Up

Down

In pathway

Ratio*

-Log10 (p value)**


Adipocyte differentiation

Bone marrow

14M

18

12

30

0.36

1.922

18M

11

19

0.486

4.436

Epididymal

14M

9

21

30

0.61

6.019

18M

8

22

0.46

2.498


Lipolysis

Bone marrow

14M

6

7

13

0.289

1.347

18M

5

8

0.263

0.87

Epididymal

14M

2

11

13

0.342

1.203

18M

2

11

0.289

0.659


Mitochondria dysfunction

Bone marrow

14M

12

18

30

0.237

1.115

18M

13

17

0.323

3.364

Epididymal

14M

3

27

30

0.24

0.487

18M

21

9

0.226

0.28


For each gene, the fold change of expression of 14-month-old (14M) and 18-month-old (18M) was calculated versus 6-month-old (6M). Pathways that have significant association with the whole set of regulated genes in bone marrow and epididymal adipocytes with age were assessed using IPA software. * Ratio of altered genes in bone marrow adipocytes to assigned pathway. **The p-value was calculated by IPA using Fisher's Exact Test. A threshold of 1.30 was selected (p < 0.05)

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

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