Table 3

Comparison of adipocyte-genes between bone marrow and epididymal adipocytes

Symbol

Entrez Gene Name

6-month

14-month

18-month


Increased expression in bone marrow

LEPR

leptin receptor

19.7

7.4

16.4

OSM

oncostatin M

18.1

20.1

11.4

RGS2

regulator of G-protein signaling 2, 24kDa

15.3

15.8

8.9

SFRP4

secreted frizzled-related protein 4

14.8

1.8

6.6

ABCB4

ATP-binding cassette, sub-family B, member 4

10.7

6.9

7.4

TNFRSF1β

CD120b

6.6

4.3

8.3

TNFα

tumor necrosis factor α

5.0

26.3

7.2

100001G20RIK

RIKEN cDNA 1100001G20 gene, Wdnm1-like

4.2

4.5

3.0

UCP2

uncoupling protein 2

4.0

2.1

3.7

LPIN2

lipin 2

4.0

3.9

5.6

TGFB1

transforming growth factor, beta 1

3.9

2.5

3.8

GPR109A

G protein-coupled receptor 109A

3.7

33.6

2.3

C/EBPβ

CCAAT/enhancer binding protein beta

2.3

6.8

1.3

IL6

interleukin 6

-1.1*

8.8

2.8


Decreased expression in bone marrow

LEP

leptin

-152.5

-300.1

-454.4

CFD

complement factor D (adipsin)

-138.2

-115.9

-107.1

RETN

resistin

-114.7

-87.4

-153.7

CDO1

cysteine dioxygenase, type I

-106.9

-132.3

-192.1

PLIN1

perilipin 1

-100.6

-85.1

-106.5

ERPINE1

plasminogen activator inhibitor type 1

-60.9

-7.0

-19.0

FASN

fatty acid synthase

-32.9

-28.5

-43.5

ADIPOQ

adiponectin

-26.4

-35.3

-41.2

FABP4

fatty acid binding protein 4, adipocyte

-23.2

-27.0

-41.3

LIPE

lipase, hormone-sensitive

-21.9

-15.2

-26.8

LPL

lipoprotein lipase

-21.8

-18.8

-23.9

KLB

klotho beta

-21.1

-12.9

-29.6

ACOX1

acyl-Coenzyme A oxidase 1, palmitoyl

-16.5

-10.2

-12.8

FGFR1

fibroblast growth factor receptor 1

-12.2

-11.4

-10.2

SLC2A4

glucose transporter member 4

-10.2

-9.5

-9.2

C/EBPα

CCAAT/enhancer binding protein, alpha

-6.7

-8.7

-11.2

PPARγ

peroxisome proliferator-activated receptor gamma

-5.9

-4.8

-10.3

IDH1

isocitrate dehydrogenase 1 (NADP+), soluble

-5.1

-4.7

-6.4

ADIPOR2

adiponectin receptor 2

-4.7

-4.0

-4.7


The list includes the most differentially expressed genes in bone marrow adipocytes compared to epididymal adipocytes. The set of the significantly differentially expressed genes was selected on the basis of their expression in adipose cells according to the IPA knowledge-base. For each gene, the fold change value in gene expression was calculated between mean values in bone marrow adipocytes versus epididymal adipocytes in mice (6-month, 14-month and 18-month old). The significance of differences was measured by one-way ANOVA. All values are p < 0.01 except * P > 0.01

Liu et al. BMC Genomics 2011 12:212   doi:10.1186/1471-2164-12-212

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