Table 4

Genes in significant Gene Ontology categories of the biological processes

GO category

Gene Name

Gene

Symbol

P value

Fold Change

(Log2FC)


HEART

Up-regulated

Translation (GO:0006412)

RNA binding motif protein 3

Rbm3

<0.001

2.863

Ribosomal protein L35A

Rpl35a

<0.001

1.857

Ribosomal protein S23

Rps23

0.001

1.793

Ribosomal protein L7A

Rpl7a

0.002

1.287

Ribosomal protein L7

Rpl7

<0.001

1.243

Eukaryotic translation elongation factor 1 beta 2

Eef1b2

0.001

1.187

Ribosomal protein S3

Rps3

0.005

1.166

Ribosomal protein L10A

Rpl10a

0.003

1.156

Eukaryotic translation initiation factor 5A

Eif5a

<0.001

1.147

Ribosomal protein S15A

Rps15a

0.008

1.116

Ribosomal protein L27

Rpl27

0.003

1.099

Lysyl-trna synthetase

Kars

<0.001

1.075

Ribosomal protein S4, X-linked

Rps4x

0.001

1.018

Ribosomal protein S13

Rps13

0.003

1.012

Ribosomal protein L30

Rpl30

0.002

1.010

Ribosomal protein S24

Rps24

0.002

1.000

Ribosomal protein, large, P0

Rplp0

0.001

0.936

Ribosomal protein L27A

Rpl27a

0.008

0.927

Ribosomal protein L22

Rpl22

0.004

0.923

Ribosomal protein L36A-like

Rpl36al

0.005

0.917

Ubiquitin A-52 residue ribosomal protein fusion product 1

Uba52

0.009

0.915

Eukaryotic translation initiation factor 3, subunit G

Eif3g

0.001

0.910

Ribosomal protein L5

Rpl5

0.002

0.900

Eukaryotic translation initiation factor 3, subunit F

Eif3f

0.003

0.884

Ribosomal protein L10A

Rpl10

0.008

0.863

Alanyl-trna synthetase domain containing 1

Aarsd1

0.006

0.838

Ribosomal protein, large, P2

Rplp2

0.001

0.732

Ribosomal protein L24

Rpl24

0.003

0.725

Ribosomal protein S27

Rps27

0.001

0.720

Eukaryotic translation initiation factor 2, subunit 3 gamma

Eif2s3

0.004

0.668

Density-regulated protein

Denr

0.007

0.651

Ribosomal protein L18A

Rpl18a

0.002

0.607

LIVER

Up-regulated

Fatty acid beta-oxidation (GO:0006635)

Acyl-Coenzyme A dehydrogenase, short/branched chain

Acadsb

0.010

0.922

Acyl-Coenzyme A dehydrogenase, very long chain

Acadvl

0.001

0.842

Hydroxyacyl-Coenzyme A dehydrogenase, beta subunit

Hadhb

0.008

0.711

Hydroxyacyl-Coenzyme A dehydrogenase, alpha subunit

Hadha

0.007

0.586

Acyl-Coenzyme A dehydrogenase, C-4 to C-12 straight chain

Acadm

0.001

0.510

Translation (GO:0006412)

Ribosomal protein L36

Rpl36

0.004

1.223

Ribosomal protein L23

Rpl23

0.003

1.002

Nascent polypeptide-associated complex alpha subunit

Naca

0.001

1.182

Eukaryotic translation elongation factor 1 delta

Eef1d

0.001

1.170

Translocated promoter region (to activated MET oncogene)

Tpr

<0.001

1.116

Ribosomal protein S6

Rps6

0.010

1.079

Ribosomal protein S20

Rps20

0.002

0.990

Ribosomal protein L34

Rpl34

<0.001

0.929

Ribosomal protein L9

Rpl9

0.005

0.829

Ribosomal protein S16

Rps16

0.001

0.808

Mediator complex subunit 8

Med8

0.004

0.683

Ribosomal protein L28

Rpl28

0.001

0.617

Protein kinase C, alpha

Prkca

0.004

0.572

Isoleucyl-trna synthetase

Iars

0.007

0.565

Down-regulated

Amino acid catabolic process (GO:0009063)

Arginase, liver

Arg1

0.009

-2.050

Glutamic-oxaloacetic transaminase 1, soluble

Got1

0.003

-1.287

Coenzyme A carboxylase, beta polypeptide

Pccb

<0.001

-1.176

Aldehyde dehydrogenase 6 family, member A1

Aldh6a1

0.006

-1.086

Methylcrotonoyl-Coenzyme A carboxylase 2 (beta)

Mccc2

0.001

-1.052

Leucine aminopeptidase 3

Lap3

0.008

-0.943

Branched chain keto acid dehydrogenase E1, beta

Bckdhb

<0.001

-0.937

Glutamic-oxaloacetic transaminase 2, mitochondrial

Got2

0.001

-0.819

Aminoadipate aminotransferase

Aadat

0.008

-0.812

Indoleamine 2,3-dioxygenase 2

Indol1

0.003

-0.810

Yippee-like 5

Ypel5

<0.001

-0.670

3-hydroxyisobutyryl-Coenzyme A hydrolase

Hibch

0.004

-0.657

Cholesterol metabolic process (GO:0008203)

Cytochrome P450, family 7, subfamily a, polypeptide 1

Cyp7a1

0.001

-2.838

Farnesyl diphosphate synthase)

Fdps

<0.001

-1.204

Acetyl-Coenzyme A acetyltransferase 2

Acat2

0.001

-1.166

Cytochrome P450, family 27, subfamily A, polypeptide 1

Cyp27a1

0.001

-1.082

Paraoxonase 1

Pon1

0.005

-0.708

7-dehydrocholesterol reductase

Dhcr7

0.001

-0.658

Emopamil binding protein (

Ebp

0.020

-0.463

Cellular respiration (GO:0045333)

Cytochrome c, somatic

Cycs

0.002

-1.139

Mitochondrial ribosomal protein S35

Mrps35

0.004

-0.859

Coenzyme Q5 homolog, methyltransferase

Coq5

0.001

-0.783

NADH dehydrogenase (ubiquinone) Fe-S protein 1

Ndufs1

0.003

-0.640

Aconitase 1

Aco1

0.001

-0.627

Succinate dehydrogenase complex, subunit C

Sdhc

0.004

-0.617

Pyruvate dehydrogenase (lipoamide) beta

Pdhb

0.008

-0.558


Symbols of genes changed in both liver and muscle are in bold.

Fedorov et al. BMC Genomics 2011 12:171   doi:10.1186/1471-2164-12-171

Open Data