Table 3

Gene Ontology categories significantly enriched with differentially expressed genes

GO Category

Total genes

on array

Changed

genes

Enrichment

FDR


Biological Process

HEART

Translation (GO:0006412)

319

32↑

3.334

<0.001

LIVER

Fatty acid beta-oxidation (GO:0006635)

22

5↑

6.805

0.036

Translation (GO:0006412)

266

28↑

3.152

<0.001

Amino acid catabolic process (GO:0009063)

36

12↓

10.202

<0.001

Cholesterol metabolic process (GO:0008203)

34

7↓

5.951

<0.001

Cellular respiration (GO:0045333)

47

7↓

4.559

0.024

Molecular Function

HEART

RNA Binding (GO:0003723)

455

35↑

2.500

<0.001

LIVER

RNA Binding (GO:0003723)

362

28↑

2.326

<0.001

Transaminase activity (GO:0008483)

10

5↓

15.468

0.001

Oxidoreductase activity, acting on the aldehyde or oxo group of donors (GO:0016903)

20

6↓

9.281

0.001

Monooxygenase activity (GO:0004497)

27

7↓

8.020

0.001

Electron carrier activity (GO:0009055)

98

11↓

3.472

0.003


Arrows indicate direction of gene regulation in hibernating black bears. FDR is false discovery rate.

Fedorov et al. BMC Genomics 2011 12:171   doi:10.1186/1471-2164-12-171

Open Data