Open Access Research article

Modulation of gene expression in heart and liver of hibernating black bears (Ursus americanus)

Vadim B Fedorov1*, Anna V Goropashnaya1, Øivind Tøien1, Nathan C Stewart1, Celia Chang2, Haifang Wang3, Jun Yan3, Louise C Showe2, Michael K Showe2 and Brian M Barnes1

Author Affiliations

1 Institute of Arctic Biology, University of Alaska Fairbanks, Fairbanks, AK 99775, USA

2 Systems Biology Division, the Wistar Institute, Philadelphia, PA 19104, USA

3 CAS-MPG Partner Institute for Computational Biology, Shanghai Institutes of Biological Sciences, 320 Yue Yang Road, Shanghai, 200031, PR China

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BMC Genomics 2011, 12:171  doi:10.1186/1471-2164-12-171

Published: 31 March 2011

Additional files

Additional file 1:

Supplementary tables. Table S1 List of differentially expressed genes identified in this study. Listed genes demonstrate significant expression differences between hibernating and summer active black bears in heart and liver tissues. Genes are ranked by log2FC (Fold Change), P is a significance level. Positive significant genes are up-regulated (positive values of log2FC) and negative significant genes are down-regulated (negative values of log2FC) in hibernating animals. Complete description of the black bear EST collection can be found in The Black Bear Gene Index at http://compbio.dfci.harvard.edu/tgi/cgi-bin/tgi/T_release.pl?gudb=bear webcite. Table S2 Primer sequences used for the real-time PCR tests in this study.

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