The clustering analysis of cancer genes using Alu-related genome features and GC content. In the text box, 22 recessive cancer genes (tumor suppressor genes) are highlighted in blue. The BRCA1, MLL, MSH2 and VHL genes (marked with underlines) are among the seven cancer genes in which Alu mediated recombination events have been reported . NUP98 (marked with red) was classified as dominant mutation in the COSMIC database but located at a cancer suppressor gene region . The gene that appears as a scalar in the dendrogram is the Huntingtin interacting protein 1 gene (HIP1).
Zhang et al. BMC Genomics 2011 12:157 doi:10.1186/1471-2164-12-157