Inflammatory response genes are enriched in two clusters within the interactive category (Category D). Expression profiles of up- and down-regulated genes in the different groups treated by cytokines and HNF4α knock-down alone (2 and 3) or in combination (4) are shown. Each group has 4 replicates. Relative expression values are expressed as a color code (bar color chart on the bottom, red up- and blue down-regulation). Inflammatory response genes (listed at the right side of the graph) extracted from GO are highly enriched in two different clusters (A and B). Gene abbreviations: VNN1, vanin 1; SAA1/SAA2, serum amyloid A1/serum amyloid A2; C5; complement component 5; CX3CL1, chemokine (C-X3-C motif) ligand 1; LBP, lipopolysaccharide binding protein; PTX3, pentraxin-related gene, rapidly induced by IL-1 beta; PTAFR, platelet-activating factor receptor; NMI, N-myc (and STAT) interactor; ORM1/ORM2, orosomucoid 1/orosomucoid 2; C4A/C4B, complement component 4A/complement component 4B; CEBPB, CCAAT/enhancer binding protein (C/EBP), beta; SERPINA3, serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; CCL20, chemokine (C-C motif) ligand 20; HIF1A, hypoxia-inducible factor 1, alpha subunit (basic helix-loop-helix transcription factor).
Wang et al. BMC Genomics 2011 12:128 doi:10.1186/1471-2164-12-128