The clustering expression profiles of up- and down-regulated genes. A global transcriptional view of HepG2 cells in response to the treatment with cytokines and HNF4α knock-down alone (2 and 3) or in combination (4) is shown. Each group has 4 replicates. Relative expression values are expressed as a color code (bar color chart on the bottom, red up- and blue down-regulation). (A), Category A contains genes that are significantly regulated by HNF4α knock-down, but not by cytokines; (B), Category B contains genes that respond to cytokine treatment, but not to HNF4α knock-down; (C), Category C contains genes whose expression is dependent on both treatments with cytokines and HNF4α knock-down in an independent manner; (D), Category D has genes that exhibit an expression pattern dependent on both treatments in an interactive manner.
Wang et al. BMC Genomics 2011 12:128 doi:10.1186/1471-2164-12-128