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Open Access Research article

Expression profile analysis of the inflammatory response regulated by hepatocyte nuclear factor 4α

Zhongyan Wang1, Eric P Bishop2 and Peter A Burke1*

Author Affiliations

1 Department of Surgery, Boston University School of Medicine, Boston, Massachusetts 02118, USA

2 Bioinformatics Graduate Program, Boston University, Boston, Massachusetts 02215, USA

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BMC Genomics 2011, 12:128  doi:10.1186/1471-2164-12-128

Published: 25 February 2011

Additional files

Additional file 1:

Genes that respond to the treatment of HNF4α knock-down and/or cytokines. This file includes four sub-tables showing the genes with significantly altered expression and fold changes in four categories (Category A to D).

Format: XLS Size: 1.6MB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Construction of HNF4α siRNA-resistant mutant. This file illustrates the generation and DNA sequencing of the HNF4α siRNA-resistant construct.

Format: PDF Size: 199KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 3:

siRNA rescue assay. This file shows the characterization of the HNF4α siRNA-resistant construct by Western blot, and the rescue effect of this construct on HNF4α knock-down responsive genes.

Format: PDF Size: 147KB Download file

This file can be viewed with: Adobe Acrobat Reader

Open Data

Additional file 4:

ELK1 and HNF4α binding motifs in HNF4α-regulated genes. This file shows the sequence and position of ELK1 and HNF4α potential binding sites in the group of HNF4α-regulated genes.

Format: XLS Size: 86KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data