Table 1

Percent of coverage of CGI loci identified from the CGI library and CpGs in the human genome by each methylation-sensitive restriction enzyme.

Enzymes

Recognition sequence

Percentage coverage of CGI locis

Percentage coverage of CpGs


Number

Percent

CGI Library

Whole genome *


HpaII (BsiSI)

CCGG

8,145

87.48%

11.31%

8.60%

Hin6I (HinP1I)

GCGC

7,877

84.60%

11.85%

6.40%

AciI (SsiI)

CCGC

8,093

86.92%

13.10%

17.40%

HpyCH4IV

ACGT

5,261

56.50%

2.88%

6.60%

BstuI

CGCG

7,154

76.83%

9.14%

NA


* Percent coverage of CpGs in the whole genome cited from Schumacher et al., 2006, Nucleic Acids Reaserach, 34(2), 528-542, which was based on a representative 100 Kb of genomic DNA derived from the Chromosome 22 COMT region.

The total number of clones on the array was 9311 and the total number of CpGs in the clones on the array was 311052.

Yang et al. BMC Genomics 2011 12:10   doi:10.1186/1471-2164-12-10

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