Table 4

List of the human genes in the INHGI with the 10 highest morbidity scores

Gene

Morbidity score

(Median [min,max])1

N

W

Wc2 (two-tailed p = 0.05)

Morbidity evidence3


Normal

Shuffled


TFRC

0.880 [0.576,0.939]

0.568 [0.447,0.678]

10

1

8*

5941956

ITGA5

0.875 [0.635,0.916]

0.491 [0.377,0.631]

10

0

8*

No evidence

LTF

0.868 [0.803,0.913]

0.509 [0.356,0.642]

10

0

8*

19258923

SFTPD

0.866 [0.618,0.923]

0.565 [0.458,0.682]

10

2

8*

19590686

THBS1

0.865 [0.831,0.918]

0.511 [0.354,0.566]

10

0

8*

18178577

TIMP2

0.860 [0.603,0.92]

0.574 [0.388,0.609]

10

0

8*

19933216

TGFB2

0.857 [0.565,0.918]

0.526 [0.407,0.707]

10

3

8*

19258923

CGA

0.856 [0.62,0.916]

0.535 [0.283,0.656]

10

0

8*

19730683

SPP1

0.856 [0.577,0.887]

0.564 [0.34,0.696]

10

0

8*

15868370

FLT1

0.854 [0.61,0.931]

0.527 [0.424,0.715]

10

3

8*

19741061

NOL3

0.850 [0.647,0.875]

0.576 [0.31,0.651]

10

1

8*

19773279


1 Of 10 scores

2 According to table of critical values for W in [6]

3 Pudmed IDs of most recent article(s) clearly stating a gene-disease association

* Difference statistically significant

Costa et al. BMC Genomics 2010 11(Suppl 5):S9   doi:10.1186/1471-2164-11-S5-S9

Open Data