Additional file 2.

Vertex degree in PPI networks according to shuffling profile category for selected species. Data come from the following species: human (A/E), mouse (F and B/G), D. melanogaster (H and C/I), C. elegans (J and D/K), C. neoformans (L), and A. thaliana (M). Boxplots and tables display, respectively, vertex degree distributions and p-values for group comparisons. Tables F, H, J, L, and M make use of all genes in PPI network, and present the results of statistical analyses concerning main text figures 3B, 3C, 3D, 3E and 3F, respectively. In contrast, boxplot/table pairs A/E, B/G, C/I, and D/K consider genes in PPI network after a paralog confluence procedure for vertices in order to control for the effect of gene duplications. In boxplots, X and O indicate arithmetic and geometric mean, respectively, whiskers mark percentiles 10 and 90, and protein length for each group is reported as mean ± standard deviation.

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Cancherini et al. BMC Genomics 2010 11(Suppl 5):S11   doi:10.1186/1471-2164-11-S5-S11