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This article is part of the supplement: Ninth International Conference on Bioinformatics (InCoB2010): Computational Biology

Open Access Proceedings

Gerontome: a web-based database server for aging-related genes and analysis pipelines

Jekeun Kwon12, Byungwook Lee1* and Haeyoung Chung23*

Author Affiliations

1 Korean BioInformation Center (KOBIC), KRIBB, Daejeon 305-806, Korea

2 Interdisciplinary Research Program of Bioinformatics, Busan National University, Busan 609-735, Korea

3 Aging Tissue Bank, College of Pharmacy, Busan National University, Busan 609-735, Korea

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BMC Genomics 2010, 11(Suppl 4):S20  doi:10.1186/1471-2164-11-S4-S20

Published: 2 December 2010

Abstract

Background

Aging is a complex and challenging phenomenon that requires interdisciplinary efforts to unravel its mystery. Insight into genes relevant to the aging process would offer the chance to delay and avoid some of deteriorative aspects of aging through the use of preventive methods. To assist basic research on aging, a comprehensive database and analysis platform for aging-related genes is required.

Results

We developed a web-based database server, called Gerontome that contains aging-related gene information and user-friendly analysis pipelines. To construct the Gerontome database, we integrated aging-related genes and their annotation data. The aging-related genes were categorized by a set of structural terms from Gene Ontology (GO). Analysis pipelines for promoter analysis and protein-ligand docking were developed. The promoter analysis pipeline allows users to investigate the age-dependent regulation of gene expression. The protein-ligand docking pipeline provides information on the position and orientation of a ligand in an age-related protein surface.

Conclusion

Gerontome can be accessed through web interfaces for querying and browsing. The server provides comprehensive age-related gene information and analysis pipelines. Gerontome is available free at http://gerontome.kobic.re.kr webcite.