Table 1

Summary of network properties for five protein sets in the human interactome

Protein set

No. of genes

No. of proteinsa

Network properties (average value)


Connectivity

Betweenness (104)

Clustering coefficient

gSPDb

cSPDc


Cancer proteins

382

342

25.41

6.29

0.13

3.63

3.20

Essential proteins

2217

1896

18.39

4.16

0.14

3.76

3.55

Control proteins

8402

8402

8.25

1.47

0.19

3.99

4.10

Recessive cancer proteins

72

69

33.03

9.82

0.13

3.61

3.05

Dominant cancer proteins

310

273

23.44

5.33

0.13

3.64

3.21


aNumber of genes whose proteins could be found in the human interactome.

bGeneral shortest-path distance between the interest proteins and the remaining proteins in the whole network.

cCharacteristic shortest-path distance among the interest proteins in the whole network.

Sun and Zhao BMC Genomics 2010 11(Suppl 3):S5   doi:10.1186/1471-2164-11-S3-S5

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