Simulation results: concentration of phoPp molecules with time with Mg2+ concentration 10–3 moles Simulation plots for the phoPp concentration change with 3 different means for the Mg2+ departure process. It can be noted that with mean = 100μs, the phoPp concentration change is quite steep, and it achieves the maximum value of phoPp (observed experimentally) in the cell at ≈ 1 sec. But as the mean is increased to 10 ms, we get acceptable estimates of the phoPp concentration. This outlines the importance of diffusion Model 2 where the mean of the Mg2+ departure process is indeed in the range of 10 ms as against the 1μs range for Model 1.
Ghosh et al. BMC Genomics 2010 11(Suppl 3):S3 doi:10.1186/1471-2164-11-S3-S3