Table 1

Summary of the different predictors and their characteristic differences among the methods.

low sequence complexity

disorder in 3D structures

fully database independent

trained on part of disorder dataset

considers alignment of related sequences


SEG [26,42]

+

-

+

-

-

CAST [23]

+

-

~#

-

-

IUPred [25]

-

+

-

-

-

DisEMBL [22]

-

+

-

+

-

DISOPRED2 [24]

-

+

-

+

+§


# scores with BLOSUM62

§ through PSI-BLAST

Different concepts of disorder applied during the development of the respective predictors are indicated by markers: "+" indicates that this concept is very relevant for this predictor, "-" indicates that this concept has not been applied and "~" indicates that this concept is indirectly implied.

Sirota et al. BMC Genomics 2010 11(Suppl 1):S15   doi:10.1186/1471-2164-11-S1-S15

Open Data