Diagram of proposed mRNA translation control pathways. Translating mRNAs are normally associated with eIF4F, which ultimately leads to the initiation of protein synthesis. In a process that can be mediated by stress sensors in the yeast cell plasma membrane, non-translating mRNAs may become associated with P-bodies that may lead to either mRNA decay or temporary sequestration of mRNAs for subsequent retrieval to the translating mRNA pool after adaptation to the stress. A novel eIF2α-P-containing complex is proposed as an alternative pathway for sequestration of non-translating RP mRNAs (blue-lined box). Asterisks identify immunoprecipitated proteins that were associated to translating or non-translating mRNAs in this study.
Rivera-Ruiz et al. BMC Genomics 2010 11:690 doi:10.1186/1471-2164-11-690