Table 1

Gene ontology (GO) categories significantly overrepresented in Holstein CNV.

Human ref. gene #

CNV gene #

Expected

P value


Pathways


Wnt signalling pathway1

348

26

10.80

0.00878


Alzheimer disease-presenilin pathway1

143

12

4.44

0.344


Cadherin signalling pathway1

168

13

5.21

0.459


Biological Process


Chemosensory perception2

207

37

6.42

8.75E-15


Olfaction2

198

36

6.14

1.88E-14


Sensory perception2

506

48

15.70

7.16E-10


G-protein-mediated signalling2

834

66

25.87

2.10E-09


Cell surface receptor-mediated signal transduction2

1638

92

50.82

6.01E-06


Signal transduction2

3406

156

105.67

1.26E-05


Transport3

1306

63

40.52

0.014


Molecular Function


G-protein-coupled receptor2

571

50

17.72

2.18E-08


Receptor2

1512

82

46.91

2.77E-05


Cell-adhesion molecule1

395

24

12.25

0.0511


Cadherin1

111

11

3.44

0.14


Transporter3

648

32

20.10

0.229


NCBI list of 25,431 Homo sapiens genes were compared to the list of 789 genes orthologous to the CNV gene content (Additional file 3) using PANTHER. 1,2,3 denote categories that are associated with overrepresentation of gene families for cadherins, olfactory receptors and transporters, respectively. The full version of this table is provided in Additional file 4.

Seroussi et al. BMC Genomics 2010 11:673   doi:10.1186/1471-2164-11-673

Open Data