Yeast two-hybrid interactome maps of PDZ domain interactions. Grey nodes represent individual PDZ domains, blue nodes represent interacting proteins having a C-terminal consensus sequence (as defined in Additional file 1) and red nodes represent interacting proteins that do not have a C-terminal consensus sequence. Red edges represent interactions identified in the AD-ORFeome yeast two-hybrid screen and black edges represent interactions identified in the AD-wrmcDNA yeast two-hybrid screen. (A) Global representation of the 674 interactions involving 469 proteins and 78 PDZ domains. (B) Promiscuity: representation of interactions involving selected target proteins with multiple PDZ domains. For multiple PDZ domains in the same protein, a ".n" extension numbered from the ATG was added to the ID of the PDZ containing protein. Some interactions have been omitted for the sake of clarity. Graphs were designed using VisANT .
Lenfant et al. BMC Genomics 2010 11:671 doi:10.1186/1471-2164-11-671