Table 2

Putative virulence factors in NRG857c genome

Locus Tag

Gene Name

Identity (%)

Function

Related Pathotype


Chromosome


Adhesins

NRG857_00540

hcpA

89

adherence

EHEC

NRG857_05010

csgE

100

assembly/transport component in curli production

Common

NRG857_17655

lpfA2

85

major fimbrial subunit of Long Polar Fimbriae (Lpf), named lpfA2

EPEC, EHEC

NRG857_21765

fimA

77

major fimbrial subunit of type 1 fimbriae

Common

NRG857_21795

fimH

99

adhesin of type 1 fimbriae

Common

Iron acquisition/Transport systems

NRG857_06120

fepC

79

ferric enterobactin transport ATP-binding protein

UPEC, EHEC

NRG857_09890

irp2

95

yersiniabactin biosynthetic protein

UPEC

NRG857_09895

irp1

91

yersiniabactin biosynthetic protein

UPEC

NRG857_09915

fyuA

95

pesticin/yersiniabactin receptor protein

UPEC

NRG857_17390

chuA

94

outer membrane receptor protein, heme utilization/transport protein

UPEC, EHEC

Capsular and somatic antigens

NRG857_14650

kpsM-II

94

involved in polysialic acid transport, group II (K1, K4, K5, K7, K12, K92...)

Haemolysins and haemagglutinins

NRG857_06035

clyA

95

cytolysin, cell lysis

ETEC

NRG857_01335

tsh

78

temperature-sensitive hemagglutinin of avian E. coli, autotransporter

APEC

Other

NRG857_00835

htrA/degP

97

stress protein, serine endoprotease

common

NRG857_02540

ompT

99

outer membrane protein 3b, other name: protease VII

common

NRG857_02570

ibeB

88

invasion gene locus (penetration of brain microvascular endothelial cells), putative resistance protein, putative outer membrane lipoprotein of copper ion antiporter

common

NRG857_04350

ompA

89

outer membrane protein (OMPA or OMPII)

common

NRG857_05660

iss2

100

gene for increased serum survival (similar to bacteriophage lambda Bor)

common

NRG857_07375

gadB

98

glutamate decarboxylase B, isozyme (amino acid catabolism and metabolism)

common

NRG857_11240

ompC

100

outer membrane protein

common

NRG857_13905

malX

94

maltose and glucose-specific IIABC component, pathogenicity island associated

UPEC

NRG857_15695

nlpI

100

lipoprotein

common

NRG857_17475

gadA

99

glutamate decarboxylase A, isozyme (amino acid catabolism and metabolism)

common

NRG857_19245

dsbA

100

oxidoreductase, thiol:disulfide interchange protein dsbA

common

NRG857_21885

ibeA

91

invasion protein, E. coli invasion of the blood-brain barrier, other name: ibe10

MENEC

Putative virulence associated genes

NRG857_00565

usp

93

uropathogenic specific protein (putative virulence island of UPEC)

UPEC

NRG857_00950

cadA

68

lysine decarboxylase

common

NRG857_03880

artJ

92

L-arginine periplasmic binding protein, supposed to be involved in virulence

common

NRG857_05150

mviM

93

putative virulence factor

common

NRG857_05155

mviN

86

putative virulence factor

common

NRG857_05410

b1121

90

hypothetical protein ycfZ, homologous to virulence factor

common

NRG857_19995

yjaA

100

hypothetical protein

common

NRG857_20725

cadA

99

Lysine decarboxylase

common

NRG857_20730

cadB

100

Lysine:cadaverine antiporter

common

NRG857_22200

nadAB

99

meningococcal adhesion, NAD biosynthesis

common


Plasmid


Colicins and microcins

NRG857_30019

cvaC

83

structural gene for microcin V

common

NRG857_30029

cma

99

structural gene for colicin M

common

Iron acquisition/Transport systems

NRG857_30008

iroB

93

siderophore

common

NRG857_30010

iroC

91

siderophore

common

NRG857_30012

iroD

99

siderophore

common

NRG857_30013

iroE

93

siderophore

common

NRG857_30015

iroN

97

siderophore

common

NRG857_30235

iutA

95

cloacin DF13/aerobactin outer membrane receptor protein

common

NRG857_30237

iucD

96

gene of the aerobactin operon, first product of the aerobactin biosynthesis pathway

common

Other

NRG857_30184

traT

84

complement resistance protein

common

NRG857_30283

ompT

76

outer membrane protein 3b, other name: protease VII

common

NRG857_30309

iss2

100

gene for increased serum survival (similar to Bacteriophage lambda Bor)

common

Antimicrobial resistance

NRG857_30085

blaTEM

94

ampicillin

common

NRG857_30067

tetC

71

tetracycline

common

NRG857_30068

tetA

91

tetracycline

common

NRG857_30075

catI

100

chloramphenicol

common

NRG857_30100

dhfrI

99

trimethoprim

common

NRG857_30095

sulII

93

sulfonamides

common

NRG857_30104

sulI

100

sulfonamides

common


Nash et al. BMC Genomics 2010 11:667   doi:10.1186/1471-2164-11-667

Open Data