Open Access Highly Accessed Research article

Comparative genomics of prevaccination and modern Bordetella pertussis strains

Marieke J Bart1,2, Marjolein van Gent1, Han GJ van der Heide1, Jos Boekhorst3, Peter Hermans2, Julian Parkhill4 and Frits R Mooi1*

1 Laboratory for Infectious Diseases and Screening, Netherlands Centre for Infectious Diseases Control, RIVM, Bilthoven, Netherlands

2 UMC St Radboud Hospital, Nijmegen, The Netherlands

3 Bioinformatics, Department of Biology, Faculty of Science, Utrecht University, The Netherlands

4 The Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK

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BMC Genomics 2010, 11:627 doi:10.1186/1471-2164-11-627

Published: 11 November 2010

Additional files

Additional file 1:

Supplementary table S1A & S1B & S1C.xlsx. Contains a list of SNPs, small insertions and deletions found in the analyzed genomes.

Format: XLSX Size: 127KB Download file

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Additional file 2:

Supplementary figure S1.jpg. Shows large regions of differences (RDs) between six Dutch B. pertussis strains and Tohama I

Format: PPTX Size: 170KB Download file

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Additional file 3:

Supplementary table S2.xlsx. Shows large Regions of Difference (RDs) between the analyzed genomes.

Format: XLSX Size: 15KB Download file

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Additional file 4:

Supplementary table S3.xlsx. Shows functional gene categories.

Format: XLSX Size: 155KB Download file

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Additional file 5:

Supplementary table S4.xlsx. Shows allelic polymorphisms found in pathogenicity-associated genes

Format: XLSX Size: 22KB Download file

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Additional file 6:

Supplementary table S5.xlsx. Shows alleles which distinguish strains isolated before and after the introduction of vaccination

Format: XLSX Size: 28KB Download file

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Additional file 7:

Supplementary table S6.xlsx. Shows alleles unique for one or both ptxP3 strains

Format: XLSX Size: 32KB Download file

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