Additional file 6.

Figure S2. Validation on MHC results with the IMAGEN dataset. In the screening IMSGC dataset, the MHC region (663 SNPs) was identified in the candidate-region approach as a mosaic of similarity and dissimilarity. 920 of the 930 couples were re-genotyped by a dense custom Illumina Platform (IMAGEN dataset: 1,078 SNPs passed quality control). (A) The pattern of similarity found in the IMAGEN dataset is comparable to that found in the screening (Figure 2). (B) 150 MHC SNPs were in common between IMAGEN and IMSGC. For each SNP passing quality control (94 SNPs), similarity between couples was calculated separately in both datasets. The correspondence of similarity scores between the two datasets was high (r2 = 0.94).

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Khankhanian et al. BMC Genomics 2010 11:626   doi:10.1186/1471-2164-11-626