Table 3

Top 10 fold-changing genes from each temporal cluster following infestation with P. ovis

Cluster ID

Gene Symbol

Gene Description

Fold Change*


Cluster 1

TMEM123

Transmembrane protein 123

19.3

CD83

CD83 molecule

9.1

ATF3

Activating transcription factor 3

7.5

CYR61

Cysteine-rich, angiogenic inducer, 61

5.4

BTG2

BTG family, member 2

5.3

EGR1

early growth response 1

4.5

CYR61 (2×)

cysteine-rich, angiogenic inducer, 61

4.5

GPR171

G protein-coupled receptor 171

4.4

GADD45B

growth arrest and DNA-damage-inducible, beta

4.1

Cluster 2

IL6

Interleukin-6

771.7

CCL2

Chemokine (C-C motif) ligand 2

35.7

CXCL2

Chemokine (C-X-C motif) ligand 2

22.7

Unknown

N/A

19.1

SELP (2×)

Selectin P (granule membrane protein 140 kDa, antigen CD62)

17.2 to 18.1

SOCS3

Suppressor of cytokine signalling 3

18.0

CSF3

colony stimulating factor 3 (granulocyte)

17.6

PDE4B

phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)

17.1

TNFAIP6

tumor necrosis factor, alpha-induced protein 6

16.7

Cluster 3

PTX3 (2×)

Pentraxin 3

225.6 to 317.2

MMP1 (2×)

Matrix metallopeptidase 1 (interstitial collagenase)

237.1 to 302.8

CXCL5

Chemokine (C-X-C motif) ligand 5

218.0

SDS

Serine dehydratase

134.3

MT1E

Metallothionein 1E

76.9

PLEK

pleckstrin

48.8

MS4A8B

membrane-spanning 4-domains, subfamily A, member 8B

45.2

SOD2

superoxide dismutase 2, mitochondrial

31.5

Cluster 4

IL8 (2×)

Interleukin-8

291.7 to 617.4

SPRR2A

Small proline-rich protein 2A

324.5

CSN2

Casein beta

174.7

SPRR2E (2×)

small proline-rich protein 2E

109.7 to 163.2

LTF

Lactotransferrin

121.9

S100A9

S100 calcium binding protein A9

90.9

ASGR2

asialoglycoprotein receptor 2

66.4

S100A12

S100 calcium binding protein A12

66.3

Cluster 5#

APOBEC2

Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2

-4.6

Unknown

N/A

-2.1

ZACN

Zinc activated ligand-gated ion channel

-2.0

HSPA8

Heat shock 70 kDa protein 8

-1.7

ADAMTS2

ADAM metallopeptidase with thrombospondin type 1 motif, 2

-1.7

FGL2

Fibrinogen-like 2

-1.6

Cluster 6

SFRP4

Secreted frizzled-related protein 4

-5.0

TXNIP (3×)

Thioredoxin interacting protein

-3.4 to -3.9

Unknown

N/A

-2.8

SERPINF1

Serpin peptidase inhibitor, clade F, member 1

-2.7

FZD2 (2×)

Frizzled homolog 2

-2.6 to -2.7

C3

Complement component 3

-2.4

FCGBP

Fc fragment of IgG binding protein

-2.3

Cluster 7

SDPR

Serum deprivation response

-19.7

NOSTRIN

nitric oxide synthase trafficker

-6.6

FAM13C

Family with sequence similarity 13, member C

-5.8

CDKN1C

Cyclin-dependent kinase inhibitor 1C (p57, Kip2)

-5.8

Unknown

N/A

-5.6

LIX1L

Lix1 homolog (mouse)-like

-5.5

SCARA5

Scavenger receptor class A, member 5 (putative)

-5.3

COL3A1

collagen, type III, alpha 1

-4.9 to -5.1

Cluster 8

CYP2F1

Cytochrome P450, family 2, subfamily F, polypeptide 1

-29.2

CAP2

CAP, adenylate cyclase-associated protein, 2

-28.5

LOR

Loricrin

-26.3

IGFBP1

Insulin-like growth factor binding protein 1

-23.4

STMN2

Stathmin-like 2

-12.9

GFRA2

GDNF family receptor alpha 2

-11.5

CYP2B

Cytochrome P450, family 2, subfamily B

-9.3

FLG

Filaggrin

-8.6

KRT1

Keratin 1

-7.0

FMO3

Flavin containing monooxygenase 3

-6.4


Key - *Fold change calculated relative to baseline samples (Time = 0), range given where 2 or more probes for a gene are present. #Cluster 5 contained only 6 genes

Burgess et al. BMC Genomics 2010 11:624   doi:10.1186/1471-2164-11-624

Open Data