Identification of genes with significant sex-biased expression in multiple tissues. A: The Venn diagrams show the number of overlapping sex-biased genes in tissues within each array platform. i: Illumina 6v1.1 and ii: Affymetrix M430v2.0. The total number of sex-balanced genes in each tissue is given within brackets and the number of shared sex-biased genes in the tissues is given in the intersecting areas. All genes in the overlapping sets are named in panel B, shaded with the same colours as in the Venn diagrams. B: Genes that were sex-biased in more than one tissue in the microarray experiments are shown. Numbers denote mean fold changes, with positive signs denoting female up-regulation and negative signs denoting male up-regulation. The genes are divided into three categories: Known X, Y-linked: Genes on the sex chromosomes that were previously described as sex-biased, including Xist, genes that escape X-inactivation and their Y-linked paralogues. Also included is 2010000I03Rik (Jpx), a gene located in the X-pairing region. Novel X, Y-linked: Genes on the sex chromosomes not previously described as sex-biased. Autosomal: Sex-biased genes located on the somatic chromosomes. Abbreviations: Chr: Chromosome, Str: Striatum, Neo: Neocortex, Hip: Hippocampus, ns: not significant, "--": not available on the array platform.
Reinius et al. BMC Genomics 2010 11:614 doi:10.1186/1471-2164-11-614