Table 2

B. azoricus genes putatively involved in immune response and inflammatory reactions.

Function

Gene Ontology n°

Gene Ontology description


Recognition

Peptidoglycan Recognition protein (PGRP)

GO: 0008745

N-acetylmuramoyl-L-alanine amidase activity

Chitin binding protein

GO:0008061; GO:0006030

Chitin binding; chitin metabolic process

Galectin 4-like protein

GO:0005529

Sugar binding

Rhamnose-binding lectin

GO:0005529

Sugar binding

Thrombospondin-like glycoprotein

GO:0007155; GO:0033627

Cell adhesion; cell adhesion mediated by integrin

Glycoside hydrolase, Chitinase-like

GO:0005975

Carbohydrate metabolic process

Mannose-6-phosphate receptor

GO:0005537

Mannose binding

Contactin associated protein 2

GO:0007155; GO:0005515

Cell adhesion; protein binding

Tissue inhibitor of metalloproteinase

GO:0008191; GO:0005578

Metalloendopeptidase inhibitor activity; proteinaceous extracellular matrix

Serpin (serine protease inhibitor)

GO:0004867

Serine-type endopeptidase inhibitor activity

α2-Macroblobulin (thioester-containing protein)

GO:0004866

Endopeptidase inhibitor activity

Syndecan binding protein

GO:0007265; GO:0005137

Ras protein signal transduction; interleukin-5 receptor binding

Fibrinogen (pattern recognition receptor)

GO:0007165; GO:0005102

signal transduction; receptor binding

Ficolin (opsonin, contain fibrinogen and collagen-like domains)

GO:0007165;GO:0005102 GO:0008228

signal transduction; receptor binding; opsonization

Scavenger receptor cysteine-rich protein (SRCR)

GO:0005044

Scavenger receptor activity

LBP/BPI (LPS binding, Crassostrea homologue)

GO:0008289

Lipid binding

Signaling

Toll-interleukin receptor

GO:0045087; GO:0007165

Innate immune response; signal transduction

Myd88

GO:0004888

Transmembrane receptor activity

TRAF (TNF receptor-associated factor)

GO:0007165; GO:0042981

Signal transduction; regulation of apoptosis

IRAK

GO:0019221; GO:0051092

Cytokine-mediated signaling pathway; regulation of NF-κB

MAPK

GO:0004672; GO:0006468

Protein kinase activity; protein amino acid phosphorylation

p38

GO:0004672; GO:0051403

Protein kinase activity; stress-activated MAPK cascade

Notch homologue

GO:0007411; GO: 0007219

Axon guidance; Notch signaling pathway

EGF receptor

GO:0007173; GO:0007165

Epidermal growth factor receptor signaling Pathway; signal transduction

TNF receptor

GO:0007165; GO:0042981

Signal transduction; regulation of apoptosis

Fibropellin homologue

GO:0005509; GO:0005515

Calcium ion binding; protein binding

Laminin_EGF

GO:0005539

Glycosaminoglycan binding

Cadherin (EGF domain containing)

GO:0016020; GO:0007156

Membrane;homophilic cell adhesion

Integrin (fibronectin receptor)

GO:0007155; GO:0007229

Cell adhesion; integrin mediated signaling pathway

Transcription

Nuclear Factor κB inhibitor

IPR015681 (InterPro)

Regulation of NF-κB activity

STAT

GO:0004871; GO:0045449

Signal transducer activity; regulation of transcription

SH2 motif(Src homology 2

GO:0007165; GO:0018108

Signal transduction; peptidyl-tyrosine phosphorylation

P53

GO:0006915; GO:0034984

Apoptosis; cellular response to DNA damage stimulus

AP-1 (Proto-oncogene c-jun)

GO:0003700; GO:0045449

Transcription factor activity; regulation of transcription

Tal (Crassostrea homologue)

GO:0045449; GO:0030528

Regulation of transcription; transcription regulator activity

Effector and modulator molecules

Defensin (big defensin)

GO:0006952

Defense response

Cytolysin

GO:0009404

Toxin metabolic process

Apolipoprotein (plasminogen)

GO:0007596; GO:0004252

Blood coagulation; serine-type endopeptidase activity

TNF (LPS-induced, α factor)

GO:0006955; GO:0006952

Immune response; defense response

Interferon

GO:0042742

Defense response to bacterium; regulation of innate immune response

TGF

GO:0006954; GO:0006917

Inflammatory response; induction of apoptosis

Glutatione peroxidase

GO:0004602; GO:0006979

Glutathione peroxidase activity; response to oxidative stress

Prostaglandin synthase/cyclooxygenase

GO:0006979; GO:0004601

Response to oxidative stress; peroxidase activity

Fibronectin

GO:0001968

Fibronectin binding

Metalloproteinase

GO:0004222; GO:0005578

Metalloendopeptidase activity; proteinaceous extracellular matrix

Metallothionein

GO:0046872

Metal ion binding

Ferritin

GO:0006879

Cellular iron ion homeostasis

Tenascin

GO:0009611; GO:0007155

Cell adhesion; response to wounding

Glucose-regulated protein 94

GO:0006950

Response to stress


Bettencourt et al. BMC Genomics 2010 11:559   doi:10.1186/1471-2164-11-559

Open Data