Table 5

Stem cell signaling pathway genes in OS epithelial regions

Accession numbers

Gene symbols

Fold change


LEC

Limbus

Cornea


WNT signalling pathway


NM_016269

LEF1

(1.2)

-

-


NM_006261

CDH1

(5.3)

-

(-5.8)


NM_013263

BRD7

(-4.0)

(1.8)

(4.0)


NM_001892

CSNK1A1

-

(4.6)

-


AF267864

TBL1XR1

-

-

(1.9)


NM_003507

FZD7

-

-

(2.0)


NM_022825

PORCN

-

-

(2.0)


NM_018890

RAC1

(-3.0)

-

(3.0)


NM_001320

CSNK2B

(-2.6)

-

(2.6)


NM_014248

RBX1

(5.6)

(-5.6)


Notch Signalling pathway


NM_014276

RBPJL

(-3.9)

-

(3.9)


NM_005524

HES1

(-1.5)

-

(2.1)


NM_203283

RBPJ

-

-

(4.6)


NM_033632

FBXW7

(-6.1)

-

(6.1)


JAK/STAT Signalling pathway


NM_004232

SOCS6

-

-

(3.9)


U52912

LEPR

(-3.4)

(-2.2)

(3.4)


U52914

LEPR

-

-

(2.3)


AJ271736

IL9R

-

(-4.2)

(4.2)


NM_000565

IL6R

-

(-8.7)

(8.7)


NM_003150

STAT3

-

-

(1.7)


NM_000297

PKD2

(-2.8)

-

(2.8)


NM_014432

IL20RA

(-4.2)

-

(4.2)


TGF-Beta Signalling pathways


NM_002165

ID1

(-3.6)

(1.5)

(3.6)


NM_006350

FST

-

-

(2.4)


NM_014248

RBX1

(5.6)

-

(-5.6)


NM_002165

ID1

(-3.6)

(1.5)

(3.6)


BMP Signalling pathway


AL096865

RUNX2

(-2.4)

-

(2.4)


NM_006350

FST

-

-

(2.4)


Hedgehog signalling pathway (HH)


NM_001892

CSNK1A1

-

(4.5)

-


NM_016004

IFT52

-

(2.5)

-


NM_005870

SAP18

(-5.3)

(-3.7)

(6.2)


The differentially expressed SC signalling molecules in the OS epithelial regions were identified with KEGGS pathways and reactome. Numbers in brackets are fold change. Negative values indicate downregulated and positive values are upregulated gene expression. No values denote absence of gene expression in the region.

Kulkarni et al. BMC Genomics 2010 11:526   doi:10.1186/1471-2164-11-526

Open Data