Table 4

Enriched canonical signaling and metabolic pathways in OS epithelial regions

Canonical metabolic pathways

P-Value

No of genes


LEC


Oxidative Phosphorylation

4.52E-17

29


Ubiquinone biosynthesis

8.04E-12

14


Purine metabolism

0.00166

18


Pyrimidine metabolism

0.0274

9


Limbus


Pentose Phosphate Pathway

0.0014

5


Oxidative Phosphorylation

0.00795

7


Valine, Leucine and Isoleucine Biosynthesis

0.00851

2


Alanine and aspartate metabolism

0.0151

3


Glycolysis/gluconeogenesis

0.047

4


Cornea


Oxidative Phosphorylation

3.48E-21

41


Ubiquinone Biosynthesis

2.14E-08

16


Purine metabolism

0.000118

30


Alanine and Aspartate metabolism

0.000869

9


Glutathione metabolism

0.00607

8


Glycolysis/gluconeogenesis

0.00855

12


Lysine biosynthesis

0.0402

2


Citrate cycle

0.042

4


Pyruvate metabolism

0.0451

8


Canonical Signaling Pathways


LEC


NRF2-mediated Oxidative Stress Response

2.29E-05

16


Nucleotide Excision Repair Pathway

3.17E-05

7


Protein Ubiquitination Pathway

2.06E-05

16


Estrogen Receptor Signaling

8.79E-03

8


Glucocorticoid Receptor Signaling

1.81E-02

13


Limbus


NRF2-mediated Oxidative Stress Response

2.81E-02

7


Regulation of actin based motility by Rho

4.51E-02

4


Cornea


NRF2 mediated Oxidative Stress Response

2.51E-04

21


Protein Ubiquitination Pathway

3.09E-07

26


Estrogen Receptor Signaling

3.67E-04

15


Antigen Presentation Pathway

1.29E-03

7


VDR/RXR Activation

6.31E-03

10


Glucocorticoid Receptor Signaling

3.05E-02

20


Nucleotide Excision repair

2.77E-04

8


Kulkarni et al. BMC Genomics 2010 11:526   doi:10.1186/1471-2164-11-526

Open Data