Additional file 4.
Simulations - null distribution histogram. The distribution of the lowest z-scores was observed in 500 simulations of selection of the AS-30CQ × AJ cross, using experimental marker positions. The null hypothesis assumed 10 loci for artemisinin resistance and 10 minor fitness alleles. The red point indicates the experimentally observed z-score (-2.364) for chr2 under artemisinin selection (Figure 3A) corresponding to a p-value of 0.0263. See Additional File 2 for details.
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Hunt et al. BMC Genomics 2010 11:499 doi:10.1186/1471-2164-11-499