Additional file 3.

Simulations - examples. Four independent examples (#1, 9, 10, 12) of simulated genome scans of comparative index (marker (AJ, drug-sensitive parent) proportion in drug-treated population/ marker proportion in untreated population) v. genome positions of markers on 14 chromosomes (numbers at top) assuming null hypothesis of 10 resistance (AS advantage, red dots) and 10 fitness (AJ advantage, blue dots) loci are shown. The z-score (Additional File 2) of the deepest valley is calculated (bottom left). Additional File 4 plots the frequency of these z-scores after 500 such simulations. Note that, in contrast to experimental scans (Figure 3A), many simulations show multiple valleys, including minor valleys containing only neutral markers.

Format: TIFF Size: 5.4MB Download file

Hunt et al. BMC Genomics 2010 11:499   doi:10.1186/1471-2164-11-499