Antisense transcription from same allele is more common than antidirectional transcription from separate alleles. (a) Schematic distinguishing these two possibilities. (b) LBP scores of antisense expressed SNPs as a function of genomic strand. Points along positively sloping diagonal correspond to antisense expression from the same allele, points along negatively sloping diagonal (red diamonds) correspond to antidirectional allele-specific expression. Diamonds correspond to validated antidirectional events. (c) Validation of allele-specific antidirectional transcription of top four candidates (three of the SNPs are from same gene). In all cases, direction of bias agreed with NSR-seq. Genomic coordinates correspond to genome release NCBI build 36.
Babak et al. BMC Genomics 2010 11:473 doi:10.1186/1471-2164-11-473