Genes mapped to cis-eQTL (Array) and genes under allele-specific expression (ASE; NSR-seq) overlap and agree on direction of allelic bias in adipose. (a) Ratio of observed to expected level of overlapping genes exceeding Genetic Additive Effect and ASE confidence scores. Histograms along the axes depict the number of genes exceeding Additive Effect or binomial-p thresholds. (b) Proportion of overlapping genes for which ASE and Additive Effect agree on direction of allelic bias (i.e. higher expression detected from B6 or BTBR allele by both approaches).
Babak et al. BMC Genomics 2010 11:473 doi:10.1186/1471-2164-11-473