Table 3 |
|||||
|
Immune-relevant genes/homologues in L. japonicus |
|||||
|
Putative Gene Catalogs |
Consensus Number |
Homologs Number in other species |
Putative Gene Catalogs |
Consensus Number |
Homologs Number in other species |
|
|
|||||
|
Pattern Recognition Genes |
T-cell and B-cell Antigen Activation |
||||
|
TLR (1-9,13,14,18,21,23) |
44 |
17 |
TCR (α,β chain) |
6 |
4 |
|
scavenger receptor |
19 |
11 |
BCL (2,3,6,7,9,10,11) and relevant |
44 |
19 |
|
Mannose receptor |
49 |
26 |
Immunoglobulin and relevant |
52 |
32 |
|
MBL |
13 |
9 |
CD (2-6,8,9,22,40,79,81,97,99,154,166, 226,276) |
47 |
29 |
|
NOD (1,2) |
7 |
5 |
BLNK |
5 |
3 |
|
C-type lectin (4,6,7,9-12) |
36 |
26 |
AICDA |
3 |
2 |
|
TOLLIP |
1 |
1 |
CBLB |
7 |
4 |
|
LPS-binding/anchor protein |
19 |
3 |
DOCK2 |
4 |
2 |
|
HMG (A,B,2L1,20A) |
8 |
6 |
DRAM |
1 |
1 |
|
LRR-containing proteins |
168 |
74 |
Glomulin |
2 |
2 |
|
NALP (1,3,4,6,9,12,13) |
21 |
8 |
HDAC (1-8,10,11) |
40 |
23 |
|
PGRP |
1 |
1 |
GALNAC4S-6ST |
5 |
3 |
|
BTK |
2 |
2 |
KLF (1-4,6-9,11-13) |
29 |
15 |
|
Fibrinogen |
4 |
4 |
IGBP1 |
1 |
1 |
|
Complement System |
HLA |
1 |
1 |
||
|
C1 (q,r,s,t),C2-C7,C9,C10 |
40 |
32 |
JAG (1,2) |
37 |
6 |
|
Complement factor (B,H,I,properdin, DAF) |
22 |
11 |
KI13B |
17 |
1 |
|
Complement receptor (1,2,5) |
13 |
8 |
LAG |
1 |
1 |
|
MASP |
4 |
3 |
NCK |
7 |
5 |
|
RGC |
2 |
2 |
Homeobox protein (NKX) |
4 |
3 |
|
Inflammatory Cytokines and Receptors |
PAWR |
3 |
3 |
||
|
IL (1,3,8,10-12,15,16,27,34) and relevant |
34 |
17 |
Protein kinase C δ |
6 |
3 |
|
ILR (1-3,6,7,10,12,15,17,18,20-22,31) and relevant |
48 |
31 |
Prolactin receptor |
5 |
2 |
|
IFN |
3 |
2 |
RAG (1,2) |
3 |
2 |
|
IFN-induced proteins and relevant |
59 |
27 |
RGS (1-5,7-9,11,12,14,16,18-20) |
47 |
23 |
|
IFN (α,β,ω) receptor |
2 |
1 |
SFTPD/SP-D |
1 |
1 |
|
IFN-related regulator |
31 |
16 |
TYK2 |
1 |
1 |
|
CRLF (1,3) |
3 |
2 |
VAV oncogene family (1-3) |
13 |
6 |
|
EBI 2 |
5 |
2 |
WAS proteins |
23 |
11 |
|
FND (3,C) |
12 |
4 |
WWP |
2 |
2 |
|
TTN/TITIN |
5 |
2 |
Antigen Processing and Regulators |
||
|
CXCL(6,12,14),CXC,CXCR(1-5,7) |
20 |
17 |
MHC I/II |
14 |
5 |
|
CCL(2-4,7,14,16,19,C11b),CCR(2-9,11) |
33 |
26 |
PSMA (1-7)/B/C/D/E(2-4) |
93 |
63 |
|
CX3CR |
1 |
1 |
Legumain |
5 |
3 |
|
XCL(1),XCR(1,1a) |
6 |
3 |
ITCH |
5 |
2 |
|
Chemokine receptor-like |
4 |
2 |
RFX5 |
4 |
1 |
|
CFLAR |
1 |
1 |
TAPBP |
3 |
2 |
|
EGF |
125 |
50 |
ASPP (1,2) |
24 |
4 |
|
FAM |
15 |
8 |
ICAM2 |
1 |
1 |
|
FGF |
23 |
14 |
RAC1 |
3 |
1 |
|
FLT3/CD135 |
2 |
2 |
AGT |
4 |
2 |
|
GATA (1-3,5,6) |
14 |
8 |
CDC (2,5-7,16,20,23,27,42,A) |
23 |
15 |
|
GDF |
3 |
3 |
CDK-inhibitor (1-3) |
9 |
8 |
|
GFI-1/-1B |
13 |
3 |
CTLA4 |
1 |
1 |
|
GPR44 |
4 |
2 |
Other Genes Related to Immune Cell Response |
||
|
Inhibin β |
1 |
1 |
CD (33,34,44,45,48,83,151,302) |
10 |
8 |
|
Integrin α/β |
89 |
38 |
Apolipoprotein A |
2 |
2 |
|
LIFR |
5 |
3 |
HELLS |
1 |
1 |
|
Lipoteichoic acid |
1 |
1 |
IMPDH/IMDH |
4 |
3 |
|
MAF |
2 |
2 |
AP-1 |
20 |
15 |
|
MIF |
3 |
2 |
c-FOS |
2 |
2 |
|
PCGF (1-3, 5, 6, A) |
8 |
6 |
EGR |
11 |
5 |
|
SCYE1/MCA |
3 |
2 |
ELK4 |
1 |
1 |
|
SDF2 |
2 |
2 |
IKKA/CHUK, IKKB |
8 |
2 |
|
TGF A/B(1-3) |
10 |
9 |
JAK (1,2) |
11 |
6 |
|
TNF and TNR |
54 |
38 |
JUN oncogene |
11 |
6 |
|
Thrombopoietin |
1 |
1 |
MALT |
5 |
2 |
|
VEGF (A,C,D) |
5 |
4 |
NFAT |
32 |
12 |
|
VEGF receptor (1-3) |
17 |
8 |
NF κ-B inhibitor proteins |
11 |
4 |
|
Adapters, Effectors and Signal Transducers |
PPM |
33 |
14 |
||
|
ASB (1-3,5-8,12,13) |
26 |
14 |
RIPK (1-3,5) |
7 |
5 |
|
CRADD |
2 |
1 |
SLC20A-1/2 |
6 |
4 |
|
DEDD |
4 |
2 |
Transcription factor Sp and SPT |
21 |
18 |
|
EIF 2-α kinase 2 |
7 |
2 |
TANK-binding kinase |
9 |
5 |
|
FADD |
1 |
1 |
TBX |
12 |
7 |
|
Heme oxygenase |
4 |
2 |
TMED (1-5,7-9,A) |
12 |
10 |
|
HTR (5A,5B) |
22 |
4 |
TRIM (1-3,7-9) |
20 |
8 |
|
IRAK (1-4) |
7 |
6 |
Antimicrobial peptide |
2 |
2 |
|
CSF |
12 |
5 |
Co-chaperone |
4 |
3 |
|
Myd88 |
2 |
1 |
Ferritin |
1 |
1 |
|
NR2C |
6 |
4 |
Hepcidin |
1 |
1 |
|
PEA15 |
2 |
1 |
HSP (7,13,70-72,74,B) |
35 |
20 |
|
PELI (1-3) |
21 |
6 |
Lysozyme |
4 |
3 |
|
PHLA (1-3) |
4 |
3 |
Macroglobulin |
9 |
6 |
|
PPARA |
2 |
2 |
Microtubule-associated |
109 |
45 |
|
REL |
1 |
1 |
Nitric oxide synthase |
4 |
3 |
|
RHOA |
3 |
1 |
Proteolipid protein |
1 |
1 |
|
RIP |
2 |
2 |
Prohibitin |
3 |
2 |
|
SARM1 |
8 |
2 |
Selenoprotein |
22 |
11 |
|
SIGIRR |
2 |
2 |
ABCF |
8 |
7 |
|
SMAD (1-7,9) |
33 |
16 |
CAMP |
13 |
4 |
|
SOCS (1-7) |
18 |
8 |
CARD |
5 |
3 |
|
TICAM1 |
1 |
1 |
CEBP |
7 |
5 |
|
TIRAP |
1 |
1 |
DMBT |
6 |
4 |
|
TRADD |
1 |
1 |
PTAFR |
1 |
1 |
|
TRAF (2-7) |
10 |
7 |
Protein S100-A |
5 |
4 |
|
TANK |
2 |
2 |
UCRP/CRP |
1 |
1 |
|
UBE |
47 |
25 |
CYBB |
1 |
1 |
|
STAT |
21 |
7 |
Caspase (1-3,6-9) |
18 |
13 |
|
NF κ |
15 |
4 |
Adenosine receptor A (2a,2b) |
11 |
7 |
|
MAPK (1-3,5-9,11-15) |
47 |
29 |
Apoptotic relevant |
13 |
6 |
|
MAP2K4(JUKK1) |
2 |
2 |
IRG1 |
4 |
2 |
|
MAP3K (2-9,11,14,15) |
35 |
18 |
Stress response protein |
22 |
6 |
|
MAP3K 7-interacting protein (TAB) |
4 |
4 |
WSC (1,2,4) |
8 |
3 |
|
JNK |
5 |
4 |
OSGI2 |
1 |
1 |
|
|
|||||
|
Putative genes/homologues were confirmed based on their similarity to immune-relevant genes in other vertebrate species as predicted by BLAST. Cutoff E-value was set to 1e-10 during BLAST analysis. Characterization of the putative genes is presented in Additional file 1, Table S1. |
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|
Xiang et al. BMC Genomics 2010 11:472 doi:10.1186/1471-2164-11-472 |
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