Overlapping Genes. (A) At 3.44 M on the KIM chromosome, a locus showing a dubious gene (y3136) overlapping two real genes, both of which have strong proteomic evidence (peptides boxed above the gene, showing orientation). Note that y3135 is completely overlapped by the dubious gene. (B) At 3.15 M two predicted proteins overlap by 206 nucleotides. There is strong proteomics evidence for the existence of glutaredoxin 1 (14 peptides), and no support for the hypothetical protein on the opposite strand. (C) At 4.04 M leuB and leuC have an overlap of 67 bp. An alignment of non-redundant leuC sequences from enterobacteria shows that the KIM version is predicted to be longer than any other close homolog.
Payne et al. BMC Genomics 2010 11:460 doi:10.1186/1471-2164-11-460