Table 6

Selected Genes and their potential regulators in rank order

Gene

TF Rank

ELOVL1

SLC34A2

SOAT1

ZDHHC3

LPCAT1

STARD4

DLK1

PRDX6

ABCA3


1

SREBP (Srebf1/2)

CEBP (Cebpa/b/g)

SREBP1 (Srebf1/2)

SREBP1 (Srebf1)

CEBP (Cebpa/b/g)

SREBP1 (Srebf1)

CEBP (Cebpa/b/g)

CEBP (Cebpa/b/g)

SREBP1 (Srebf1)


2

CEBP (Cebpa/b/g)

ETS1 (Ets1)

ZIC2 (Zic2)

GATA (Gata6)

SREBP1 (Srebf1)

CEBP (Cebpa/b/g)

HNF3 (Foxa1/2)

SREBP (Srebf1/2)

HNF3 (Foxa1/2)


3

HNF3 (Foxa1/2)

STAT6 (Stat6)

CEBP (Cebpa/b/g)

HNF3 (Foxa1/2)

NFAT (Ilf3, Nfatc3)

ETS1 (Ets1)

KROX (Egr1)

NFKB (Nfkb1)

TTF1 (Nkx2-1)


4

TTF1 (Nkx2-1)

SREBP1 (Srebf1/2)

KROX (Egr1)

XFD1 (NP)

ETS1 (Ets1)

FOXP3 (NP)

SREBP1 (Srebf1)

ETS1 (Ets1)

EGR (Egr1)


5

TCF4 (Tcf4)

ERR1 (Esrra)

UF1H3B (Foxa1/2)

IRF1 (Irf1)

EGR (Egr1)

HNF3 (Foxa1/2)

HNF1 (Hnf1a/1b)

HNF3 (Foxa1/2)

KROX (Egr1)


6

NFKB (Nfkb1)

LMO2COM (Lmo2)

IRF1 (Irf1)

FREAC7 (NP)

STAT6 (Stat6)

ETS2 (Ets2)

TAXCREB (Creb1)

TTF1 (Nkx2-1)

E2F (E2f1-5)


7

ZIC2 (Zic2)

HEB (Tcf12)

LXR (Nr1h2)

TTF1 (Nkx2-1)

E2F (E2f1-5)

ATF1 (Atf1)

GATA1 (Gata1)

TCF4 (Tcf4)

CEBP (Cebpa/b/g)


8

SMAD4 (Smad4)

HNF3 (Foxa1/2)

LMO2COM (Lmo2)

EGR (Egr1)

GATA1 (Gata1)

HNF4A (Hnf4a)

ETS1 (Ets1)

NRF2 (Gabpa)

GATA (Gata6)


9

BARBIE (NP)

TATA (Tbp)

WT1 (Wt1)

ZF5 (Zfp161)

IRF1 (Irf1)

GATA3 (Gata6)

WT1 (Wt1)

SMAD4 (Smad4)

ZNF219 (Zfp219)


10

ETS2 (Ets2)

HNF4A (Hnf4a)

SMAD4 (Smad4)

AP2G (Tcfap2c)

AP2G (Tcfap2c)

ERR1 (Esrra)

STAT (Stat3)

GRE (Nr3c1)

WT1 (Wt1)


Genes were selected based on their functional relevance to surfactant biosynthesis/transport. For each gene of interest, its potential TF regulators were predicted in rank order of TF-TG confidence score and TF-TG relationships were supported by promoter assay. Top 10 TFBS and their corresponding TF in lung are listed under the selected genes.

Xu et al. BMC Genomics 2010 11:451   doi:10.1186/1471-2164-11-451

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