Additional file 9.

Sequence comparison of the chlamydial plasmid. Multiple sequence alignment of the predicted amino acid sequence from C. pneumoniae koala LPCoLN (pCpnKo), C. pneumoniae horse N16 (pCpnE1), C. psittaci avian N352 (pCpA1), C. felis feline Fe/C-56 (pCfe1), C. caviae guinea pig GPIC (pCpGP1), C. muridarum mouse Nigg (pMoPn) and C. trachomatis human serovars A (pCTA), B (pJALI), E (pSW2) and L1 (pLVG440). The sequences are well-conserved across species, indicating some degree of ancestry among them. The C. pneumoniae plasmid shared a close relationship with C. psittaci, C. caviae and C. felis, while C. muridarum and C. trachomatis were highly conserved. Predicted functions include plasmid replication (ORF1 and ORF2), double-stranded DNA unwinding (ORF3), chlamydial pathogenesis (ORF5) and regulation of partitioning and copy number (ORF7 and ORF8) [34,67]. The functions of ORF4 and ORF6 remain to be determined.

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Mitchell et al. BMC Genomics 2010 11:442   doi:10.1186/1471-2164-11-442