The probabilistic model. For each species, only three prototypes are represented here, while several dozens are usually used. Prototypes are modeled with multivariate Gaussian models represented here by series of means and standard deviations. P. falciparum prototypes are labeled with their prior probabilities. Prior probabilities of the prototype of the reference species are on the outgoing transitions from the mute state M. Direct transitions corresponding to evolutionary conservation between prototypes are in bold.
Bréhélin et al. BMC Genomics 2010 11:35 doi:10.1186/1471-2164-11-35