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Open Access Research article

Integrative analysis of the heat shock response in Aspergillus fumigatus

Daniela Albrecht1, Reinhard Guthke1, Axel A Brakhage23 and Olaf Kniemeyer23*

Author Affiliations

1 Research Group Systems Biology/Bioinformatics, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany

2 Department of Molecular and Applied Microbiology, Leibniz Institute for Natural Product Research and Infection Biology, Hans-Knöll-Institute, Jena, Germany

3 Friedrich Schiller University, Jena, Germany

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BMC Genomics 2010, 11:32  doi:10.1186/1471-2164-11-32

Published: 15 January 2010

Additional files

Additional file 1:

MS_results. Results of the MALDI-TOF/TOF analysis of protein spots with significant change in abundance after heat shock.

Format: XLS Size: 45KB Download file

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Additional file 2:

Funcat. FunCat annotations for all 64 differentially regulated proteins on most detailed (sheet1), second general (sheet2) and most general level (sheet4), including enrichment analysis of second level annotations (sheet3).

Format: XLS Size: 127KB Download file

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Additional file 3:

Time_series_tr_pr. Graphical display of the time series data of differentially expressed transcripts and proteins. Only significantly regulated proteins/transcripts are depicted. Time is given in minutes and the relative abundance of protein spots in log2 ratios. Each pair of a transcript and its respective protein is displayed in a separate plot. Transcripts are depicted in red, proteins in blue. If there were several spots representing the same protein, several blue lines were drawn.

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Additional file 4:

Sequence_analysis. Detected Hsf1 binding motifs in the upstream region of the genes representing the differentially regulated proteins (sheet1) and yeast homologues with their regulation (sheet2).

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Additional file 5:

Workflow. The DIGE analysis workflow of this study.

Format: TIFF Size: 311KB Download file

Open Data