p53 results. Top: ROC curves for cross-validation on p53 data set using random genomic sequences as counter-examples. Bottom: A known TRANSFAC motif for p53 and the motifs our gapped method and MEME found. Using our method, 3% of the sites discovered had an optional spacer between the 2 half-sites. This is a close fit to Wei et al.'s analysis. They found 236 sites without a spacer and 27 that had a 1 base pair spacer.
Reid et al. BMC Genomics 2010 11:30 doi:10.1186/1471-2164-11-30