Classes from constituent runs — T+C versus A+T. The classes found from each of the 8 preliminary replication runs have been overlaid on the same plot. The classes have been plotted by their A+T and T+C content as in Figure 1A, except that the figure includes only classes with T+C > 0.5 — the omitted classes mirror those shown. The plot shows a strong similarity between the results of the replication runs, showing the reproducibility of the method--a point taken up in Figure 8. Each replication run was randomly initialised with 25 pairs of matched classes, and trained on 6000 sequences of 2000 bases taken at random from the human genome.
Evans BMC Genomics 2010 11:286 doi:10.1186/1471-2164-11-286