Table 6

Metacore analysis of the pathways modified by 1,25(OH)2D treatment in RWPE1 cells (p < 0.05).

Metacore Map

p-Value

Genes changed


6 h induced: 83 maps at p < 0.05

Apoptosis and survival_NGF activation of NF-kB

2.89E-03

6

Transcription: p53 signaling pathway

2.33E-02

5

Inhibitory action of Lipoxins on pro-inflammatory TNF-alpha signaling

2.33E-02

5

Arachidonic acid production

1.76E-03

6

6 h suppressed: 28 maps at p < 0.05

Transcription_NF-kB signaling pathway

2.29E-02

4

Development_WNT signaling pathway. Part 2

1.48E-02

6

Development_Notch signaling pathway

4.17E-02

4

Transcription_Androgen receptor nuclear signaling

3.68E-02

5

24 h induced: 30 maps at p < 0.05

Oxidative phosphorylation

5.66E-04

13

Cell adhesion_ECM remodeling

2.02E-02

7

Role of tetraspanins in the integrin-mediated cell adhesion

4.62E-02

6

Prostaglandin 2 biosynthesis and metabolism FM

2.93E-03

5

24 h suppressed: 84 maps at p < 0.05

Immune response_IL6 signaling pathway

3.85E-03

10

Immune response_IFN gamma signaling pathway

2.06E-04

9

Cell cycle Nucleocytoplasmic transport of CDK/Cyclins

6.04E-05

7

Cell cycle_Role of APC in cell cycle regulation

7.19E-03

6

48 h induced: 53 maps at p < 0.05

Cell cycle_Regulation of G1/S transition (part 2)

6.07E-03

6

Oxidative phosphorylation

2.17E-02

11

Regulation of lipid metabolism_Insulin regulation of fatty acid metabolism

1.37E-02

8

Glycolysis and gluconeogenesis (short map)

3.43E-03

7

Apoptosis and survival_p53-dependent apoptosis

3.54E-02

5

Prostaglandin 2 biosynthesis and metabolism FM

1.27E-03

6

48 h suppressed: 140 maps at p < 0.05

Cell cycle_Role of APC in cell cycle regulation

2.92E-04

14

Immune response_Antiviral actions of Interferons

4.07E-05

16

Immune response_PGE2 common pathways

5.22E-04

16

Development_TGF-beta receptor signaling

3.94E-04

15

Development_VEGF-family signaling

1.68E-02

9

Peroxisomal branched chain fatty acid oxidation

3.51E-04

8

All times induced: 66 maps at p < 0.05

Cytoskeleton remodeling_Keratin filaments

8.37E-04

13

Development_TGF-beta receptor signaling

8.65E-03

13

Development_VEGF signaling and activation

3.92E-02

10

Cell Adhesion_ECM remodeling

3.94E-02

11

Apoptosis and survival_caspase cascade

6.47E-03

9

All times suppressed: 155 maps at p < 0.05

Immune Response_IL-27 signaling pathway

3.14E-04

12

Development_Notch Signaling Pathway

5.70E-04

16

Cell cycle_Regulation of G1/S transition (part 1)

6.25E-07

24

Transcription_Androgen Receptor nuclear signaling

3.38E-03

18

Cell adhesion_Ephrins signaling

8.47E-03

14

Development_VEGF-family signaling

3.86E-02

10


Kovalenko et al. BMC Genomics 2010 11:26   doi:10.1186/1471-2164-11-26

Open Data