Table 5 |
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|
GenMAPP analysis of the pathways and biological processes modified by 1,25(OH)2D treatment in RWPE1 cells. |
|||||||
|
MAPP Name |
%1 |
Z2 |
P3 |
MAPP Name |
% |
Z |
P |
|
|
|||||||
|
6 h Local maps (Induced): 24 maps at P < 0.1 |
6 h Local maps (Suppressed): 12 maps at P < 0.1 |
||||||
|
Oxidative Stress |
35 |
5.7 |
0 |
Wnt Signaling |
11 |
2.2 |
0.035 |
|
MAPK signaling pathway KEGG |
13 |
3.2 |
0.002 |
IL-1 NetPath 13 |
11 |
1.8 |
0.076 |
|
2-Tissues-Muscle, Fat and Connective |
15 |
2.4 |
0.031 |
Phosphatidylinositol signaling system |
8 |
1.8 |
0.091 |
|
TGFβ signaling pathway |
10 |
1.8 |
0.092 |
||||
|
6 h GO Biological process (Induced): 236 maps at P < 0.1 |
6 h GO Biological process (Suppressed): 181 maps at P < 0.1 |
||||||
|
Cell differentiation (30154) |
5 |
2.0 |
0.062 |
Cell proliferation (8283) |
7 |
3.6 |
0 |
|
Response to stress (6950) |
12 |
3.2 |
0 |
Positive regulation of cell proliferation (8284) |
8 |
1.8 |
0.072 |
|
Apoptosis (8219) |
30 |
2.4 |
0.013 |
Anti-apoptosis (6916) |
10 |
3.1 |
0.007 |
|
Regulation of transcription from RNA polymerase II promoter (6357) |
10 |
2.5 |
0.013 |
Transcriptional repressor activity (16564) |
7 |
2.1 |
0.039 |
|
Signal transduction (7165) |
13 |
7.9 |
0 |
Signal transduction (7165) |
5 |
2.8 |
0.007 |
|
Lipid metabolism (6629) |
7 |
2.1 |
0.035 |
||||
|
24 h Local maps (Induced): 19 maps at P < 0.1 |
24 h Local maps (Suppressed): 19 maps at P < 0.1 |
||||||
|
Oxidative Stress |
23 |
3.4 |
0.005 |
Delta-Notch NetPath 3 |
15 |
4.2 |
0.001 |
|
Sterol biosynthesis |
28 |
3.6 |
0.003 |
Focal adhesion KEGG |
12 |
4.0 |
0.001 |
|
Nitrogen metabolism |
33 |
4.2 |
0.005 |
Hedgehog NetPath 10 |
27 |
4.0 |
0.011 |
|
Glycolysis and Gluconeogenesis |
15 |
2.3 |
0.036 |
TGF receptor NetPath 7 |
10 |
2.8 |
0.009 |
|
2-Tissues-Muscle, Fat and Connective |
26 |
5.4 |
0 |
Androgen-Receptor NetPath 2 |
10 |
2.4 |
0.022 |
|
24 h GO Biological process (Induced): 260 maps at P < 0.1 |
24 h GO Biological process (Suppressed): 294 maps at P < 0.1 |
||||||
|
Lipid metabolism (6629) |
9 |
3.1 |
0.003 |
Cell proliferation (8283) |
8 |
3.5 |
0.001 |
|
Cell adhesion (7155) |
9 |
2.4 |
0.014 |
Cell motility (6928) |
11 |
4.4 |
0 |
|
Development (7275) |
7 |
2.2 |
0.032 |
Immune response (6955) |
8 |
4.5 |
0 |
|
Ion transport (6811) |
9 |
2.8 |
0.01 |
Signal transduction (7165) |
6 |
5.4 |
0 |
|
48 h Local maps (Induced): 24 maps at P < 0.1 |
48 h Local maps (Suppressed): 25 maps at P < 0.1 |
||||||
|
Oxidative Stress |
23 |
2.7 |
0.013 |
Inflammatory Response Pathway |
60 |
5.4 |
0 |
|
Glutathione metabolism |
22 |
2.2 |
0.061 |
Delta-Notch NetPath 3 |
22 |
2.3 |
0.017 |
|
Nitrogen metabolism |
47 |
5.4 |
0 |
Focal adhesion KEGG |
23 |
3.8 |
0 |
|
Glycerolipid metabolism |
18 |
3.0 |
0.006 |
TGF receptor NetPath 7 |
23 |
3.7 |
0 |
|
2-Tissues-Muscle, Fat and Connective |
28 |
5.0 |
0 |
Androgen-Receptor NetPath 2 |
23 |
2.9 |
0.003 |
|
48 h GO Biological process (Induced): 242 maps at P < 0.1 |
48 h GO Biological process (Suppressed): 245 maps at P < 0.1 |
||||||
|
Lipid metabolism (6629) |
12 |
5.6 |
0 |
Cell proliferation (8283) |
19 |
4.3 |
0 |
|
Steroid metabolism (8202) |
15 |
3.8 |
0 |
Extracellular matrix (31012) |
28 |
5.7 |
0 |
|
Cell adhesion (7155) |
13 |
3.2 |
0.001 |
Immune response (6955) |
26 |
8.5 |
0 |
|
Cell redox homeostasis (45454) |
33 |
2.6 |
0.033 |
Angiogenesis (1525) |
36 |
3.8 |
0 |
|
Ion transport (6811) |
12 |
4.2 |
0 |
Signal transduction (7165) |
14 |
3.4 |
0.005 |
|
|
|||||||
|
1% = percent in map changed; 2Z = Z score; 3P = permuted P value |
|||||||
|
Kovalenko et al. BMC Genomics 2010 11:26 doi:10.1186/1471-2164-11-26 |
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