Table 5

GenMAPP analysis of the pathways and biological processes modified by 1,25(OH)2D treatment in RWPE1 cells.

MAPP Name

%1

Z2

P3

MAPP Name

%

Z

P


6 h Local maps (Induced): 24 maps at P < 0.1

6 h Local maps (Suppressed): 12 maps at P < 0.1

Oxidative Stress

35

5.7

0

Wnt Signaling

11

2.2

0.035

MAPK signaling pathway KEGG

13

3.2

0.002

IL-1 NetPath 13

11

1.8

0.076

2-Tissues-Muscle, Fat and Connective

15

2.4

0.031

Phosphatidylinositol signaling system

8

1.8

0.091

TGFβ signaling pathway

10

1.8

0.092

6 h GO Biological process (Induced): 236 maps at P < 0.1

6 h GO Biological process (Suppressed): 181 maps at P < 0.1

Cell differentiation (30154)

5

2.0

0.062

Cell proliferation (8283)

7

3.6

0

Response to stress (6950)

12

3.2

0

Positive regulation of cell proliferation (8284)

8

1.8

0.072

Apoptosis (8219)

30

2.4

0.013

Anti-apoptosis (6916)

10

3.1

0.007

Regulation of transcription from RNA polymerase II promoter (6357)

10

2.5

0.013

Transcriptional repressor activity (16564)

7

2.1

0.039

Signal transduction (7165)

13

7.9

0

Signal transduction (7165)

5

2.8

0.007

Lipid metabolism (6629)

7

2.1

0.035

24 h Local maps (Induced): 19 maps at P < 0.1

24 h Local maps (Suppressed): 19 maps at P < 0.1

Oxidative Stress

23

3.4

0.005

Delta-Notch NetPath 3

15

4.2

0.001

Sterol biosynthesis

28

3.6

0.003

Focal adhesion KEGG

12

4.0

0.001

Nitrogen metabolism

33

4.2

0.005

Hedgehog NetPath 10

27

4.0

0.011

Glycolysis and Gluconeogenesis

15

2.3

0.036

TGF receptor NetPath 7

10

2.8

0.009

2-Tissues-Muscle, Fat and Connective

26

5.4

0

Androgen-Receptor NetPath 2

10

2.4

0.022

24 h GO Biological process (Induced): 260 maps at P < 0.1

24 h GO Biological process (Suppressed): 294 maps at P < 0.1

Lipid metabolism (6629)

9

3.1

0.003

Cell proliferation (8283)

8

3.5

0.001

Cell adhesion (7155)

9

2.4

0.014

Cell motility (6928)

11

4.4

0

Development (7275)

7

2.2

0.032

Immune response (6955)

8

4.5

0

Ion transport (6811)

9

2.8

0.01

Signal transduction (7165)

6

5.4

0

48 h Local maps (Induced): 24 maps at P < 0.1

48 h Local maps (Suppressed): 25 maps at P < 0.1

Oxidative Stress

23

2.7

0.013

Inflammatory Response Pathway

60

5.4

0

Glutathione metabolism

22

2.2

0.061

Delta-Notch NetPath 3

22

2.3

0.017

Nitrogen metabolism

47

5.4

0

Focal adhesion KEGG

23

3.8

0

Glycerolipid metabolism

18

3.0

0.006

TGF receptor NetPath 7

23

3.7

0

2-Tissues-Muscle, Fat and Connective

28

5.0

0

Androgen-Receptor NetPath 2

23

2.9

0.003

48 h GO Biological process (Induced): 242 maps at P < 0.1

48 h GO Biological process (Suppressed): 245 maps at P < 0.1

Lipid metabolism (6629)

12

5.6

0

Cell proliferation (8283)

19

4.3

0

Steroid metabolism (8202)

15

3.8

0

Extracellular matrix (31012)

28

5.7

0

Cell adhesion (7155)

13

3.2

0.001

Immune response (6955)

26

8.5

0

Cell redox homeostasis (45454)

33

2.6

0.033

Angiogenesis (1525)

36

3.8

0

Ion transport (6811)

12

4.2

0

Signal transduction (7165)

14

3.4

0.005


1% = percent in map changed; 2Z = Z score; 3P = permuted P value

Kovalenko et al. BMC Genomics 2010 11:26   doi:10.1186/1471-2164-11-26

Open Data