Additional file 13.
1,25(OH)2D suppresses proinflammatory cytokine signaling. Figure representing regulation of transcripts controlling cytokine signaling in RWPE1 cells by 1,25(OH)2D treatment (100 nM). Differentially expressed transcripts (SAM, any time point, FDR<5%) were examined for functional changes using GenMAPP and GSA. A large number of pathways related to the signaling through cytokine pathways were identified as down-regulated. Most of these pathways utilize a JAK-STAT intracellular signaling pathway. A selection of transcripts affected and their relationship to JAK-STAT signaling are shown.
Format: TIFF Size: 258KB Download file
Kovalenko et al. BMC Genomics 2010 11:26 doi:10.1186/1471-2164-11-26