Research article
Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
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* Corresponding author: Dalu T Mancama dmancama@csir.co.za
- † Equal contributors
1 CSIR Biosciences, PO Box 395, Pretoria, 0001, South Africa
2 Department of Biochemistry, University of Pretoria, Pretoria, Gauteng, 0002, South Africa
BMC Genomics 2010, 11:235 doi:10.1186/1471-2164-11-235
Published: 12 April 2010Additional files
Additional file 1:
Table S1. Pearson correlations between individual slides processed in the study. Pearson correlations between technical and biological replicates of slides at each time point in solvent control and drug-treated samples.
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Additional file 2:
Table S2. Differentially expressed up- and downregulated genes at each time point following analysis. PlasmoDB IDs and annotations of differentially expressed and unique up- and downregulated genes at each time point. Overall unique up- and downregulated genes are also listed.
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Additional file 3:
Table S3. Differentially affected proteins at each time point following cyclohexylamine inhibition. Protein response (up- or downregulation), response time point and regulation of the encoding transcripts are indicated. Additionally, protein pI, MW, matched peptides and Protein Pilot scores are shown. Proteins involved in polyamine biosynthesis are indicated in bold.
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