Plasmodium falciparum spermidine synthase inhibition results in unique perturbation-specific effects observed on transcript, protein and metabolite levels
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* Corresponding author: Dalu T Mancama dmancama@csir.co.za
- † Equal contributors
BMC Genomics 2010, 11:235 doi:10.1186/1471-2164-11-235
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BioMed Central: 2 citations
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Research
John VW Becker, Marina M van der Merwe, Anna C van Brummelen, Pamisha Pillay, Bridget G Crampton, Edwin M Mmutlane, Chris Parkinson, Fanie R van Heerden, Neil R Crouch, Peter J Smith, Dalu T Mancama, Vinesh J Maharaj Malaria Journal 2011, 10:295 (11 October 2011) Paper investigates the anti-plasmodial effect of the South African medicinal plant Dicoma anomala subsp. gerrardii, based on its ethnomedicinal profile. Using conventional fractionation and purification techniques, authors were able by various chemical techniques to identify the most active anti-plasmodial compound in the in vitro P. falciparum as dehydrobrachylaenolide, a sesquiterpene lactone.
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Oral presentation
Investigating transcriptional regulation of Plasmodium falciparum upon drug perturbation Tharina van Brummlen, John VW Becker, Dalu T Mancama, Heinrich Hoppe Malaria Journal 2010, 9(Suppl 2):O32 (20 October 2010) |