Open Access Highly Accessed Research article

Evolutionary conservation of essential and highly expressed genes in Pseudomonas aeruginosa

Andreas Dötsch1, Frank Klawonn34, Michael Jarek2, Maren Scharfe2, Helmut Blöcker2 and Susanne Häussler15*

Author Affiliations

1 Chronic Pseudomonas Infections Research Group, Helmholtz-Center for Infection Research, Braunschweig, Germany

2 Department of Genome Research, Helmholtz-Center for Infection Research, Braunschweig, Germany

3 Project Group Bioinformatics and Statistics, Helmholtz-Center for Infection Research, Braunschweig, Germany

4 Department of Computer Science, University of Applied Sciences Braunschweig/Wolfenbüttel, Wolfenbüttel, Germany

5 Twincore, Center for Experimental and Clinical Infection Research, joint venture of the Helmholtz Center for Infection Research and the Medical School Hannover, Hannover, Germany

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BMC Genomics 2010, 11:234  doi:10.1186/1471-2164-11-234

Published: 9 April 2010

Additional files

Additional file 1:

Overview of the clinical strains included in the sequenced pools. This table specifies the strains that were merged in the three sequence pools and their clinical source.

Format: XLS Size: 21KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data

Additional file 2:

Complete list of proteins with full conservation of the amino acid sequence. All 980 genes identified to show no sequence variation at the protein level (nonsynonymous substitution rate dN = 0) in all three sequence pools are listed in this xls file. Additional information includes gene annotation, experimental essentiality, phylogenetic distribution of orthologs and effect on antibiotic susceptibility.

Format: XLS Size: 213KB Download file

This file can be viewed with: Microsoft Excel Viewer

Open Data